Rami Malek as Laurence Cooper, a 1920's actor who is a wise-cracking everyday man.

Soulja Boy as Mapper McQueen, a cocky, short-tempered rapper who has fallen into obscurity.Pharrell Williams as Cool Spot, an eccentric anthropomorphic red dot that sports sunglasses and often proclaims himself as the coolest person in Pop City, who is now the coolest person on the planet and is the husband of Eve Coke.Set 4 years after the original film, Cool Spot, who has now risen to newfound worldwide fame and finally marries his longtime girlfriend Eve Coke while having kids with her, finds himself trapped in a projector after being tricked into thinking he's having a movie based on himself where he must save his friends from death with the help of Kool-Aid Man who just recently gotten out of prison and more new friends while being pitted against an old rival. The film is scheduled to be released on January 28, 2022, by 20th Century Studios.

This film will be the final performance by DMX before his death and will be dedicated in his memory.

Most of the cast members such as Pharrell Williams and Mila Kunis will reprise their roles from the original film along with new cast members such as Soulja Boy, Rami Malek, Chris Hemsworth, Timothée Chalamet, and Young Thug. It is the sequel to 2018's Cool Spot which in turn is based on the 1993 video game of the same name. Template:Infobox film Cool Spot: Spot Goes to Hollywood (also known as Cool Spot 2) is an upcoming American computer-animated comedy film produced by 20th Century Animation and Virgin Produced and directed by Phil Lord and Christopher Miller.

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